Dual-responsive nanosystem for precise molecular subtyping and resistant reversal of EGFR targeted therapy - Details

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Abstract：

The　clinical　outcome　of　epidermal　growth　factor　receptor　(EGFR)tyrosine　kinase　inhibitors　is　limited　by　the　ambiguous　molecular　subtypes　of　non-small　cell　lung　cancer　(NSCLC)patients　and　the　emergence　of　drug-resistance.　Here,　a　nanotheranostic　agent　ECMI,　which　is　indocyanine　green　(ICG)-loaded　mesoporous　silica　nanoparticles　lidded　with　ZnO　QDs　and　wrapped　with　erlotinib-modified　chitosan,　was　developed　for　accurately　determination　of　molecular　subtypes　and　synergistic　therapy.　The　erlotinib　could　guide　ECMI　into　EGFR-mutated　NSCLC　cells　and　acquire　a　pH/redox　dual-responsive　release　of　ICG　for　precise　fluorescent　imaging.　The　ECMI　could　exert　synergistic　photodynamic/molecular　targeted　therapeutic　effects　under　near-infrared　irradiation　in　either　erlotinib-sensitive　or　erlotinib-resistant　EGFR-mutated　NSCLC　cells.　In　vivo　experiments　further　showed　that　ECMI　had　distinct　distribution　behaviors　in　different　NSCLC　models　and　demonstrated　synergistic　anticancer　effects.　These　results　indicated　that　ECMI　could　be　a　promising　nanotheranostic　agent　to　treat　EGFR-mutated　NSCLC,　and　could　provide　a　new　perspective　for　individualized　treatment.　©　2019　Elsevier　B.V.

Keyword：

Erlotinib; Nanotheranostics; Near-infrared fluorescence imaging; NSCLC; PDT therapy; Synergistic therapy

Community：

[ 1 ] [Zhang, Y.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 2 ] [Zhang, Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 3 ] [Zhang, L.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 4 ] [Zhang, L.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 5 ] [Lin, X.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 6 ] [Lin, X.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 7 ] [Ke, L.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 8 ] [Ke, L.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 9 ] [Li, B.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 10 ] [Li, B.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 11 ] [Xu, L.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 12 ] [Xu, L.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 13 ] [Lv, T.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 14 ] [Lv, T.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 15 ] [Li, Z.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 16 ] [Li, Z.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 17 ] [Chen, H.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 18 ] [Chen, H.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China
[ 19 ] [Gao, Y.]Cancer Metastasis Alert and Prevention Center, and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China
[ 20 ] [Gao, Y.]Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, Fujian 350116, China

Reprint 's Address：

[Gao, Y.]Cancer Metastasis Alert and Prevention Center, College of Chemistry, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou UniversityChina

Email：

hellogaoyu@126.com

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Source ：

Chemical Engineering Journal

ISSN： 1385-8947

Year： 2019

Volume： 372

Page： 483-495

1 0 . 6 5 2

JCR@2019

1 3 . 4 0 0

JCR@2023

ESI HC Threshold：150

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count： 0

SCOPUS Cited Count： 36

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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