The　conventional　injectable　hydrogels　as　wound　dressing　materials　frequently　encounter　bacterial　infection　and　lack　self-healing　ability.　Besides,　the　hydrogels　injected　into　the　irregular　wound　sites　are　easily　damaged　by　external　forces,　which　further　hinder　wound　healing.　To　make　up　for　these　deficiencies,　we　developed　a　novel　hydrogel　with　the　unique　properties　including　dynamic　covalent　based　self-healing,　antibacterial　and　sequential　drug　release.　This　injectable　and　self-healing　hydrogel　was　constructed　via　the　dynamic　reaction　of　aminated　gelatin　(NGel),　adipic　acid　dihydrazide　(ADH)　and　oxidized　dextran　(ODex).　After　injection　or　damage,　the　broken　hydrogel　pieces　performed　excellent　self-healing　capability　to　generate　an　integral　hydrogel　owing　to　dynamic　imine　and　acylhydrazone　bonds.　Meanwhile,　bFGF@PLGA　microspheres　and　chlorhexidine　acetate　(CHA)　were　embedded　into　the　hydrogels.　This　bFGF@PLGA/CHA/hydrogel　presented　a　good　biodegradability,　and　it　could　retain　the　morphological　stability　after　swelling.　Moreover,　bFGF@PLGA/CHA/hydrogels　achieved　the　sequential　release　of　CHA　and　bFGF　during　the　drug　release　assay.　When　topically　applied　onto　the　wound　skin　of　rats,　the　hydrogels　can　effectively　prevent　infection　at　the　early　stages　due　to　the　rapid　release　of　CHA,　then　further　accelerate　cell　proliferation　and　wound　healing　through　the　sustained　release　of　bFGF.　These　results　indicate　that　the　proposed　self-healing　hydrogel　with　sequential　release　properties　is　a　highly　promising　dressing　material　for　wound　healing.　©　2019　Elsevier　B.V.