Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as a Powerful Strategy for Enhancing Photothermal-Immunotherapy Efficiency of Solid Tumors - Details

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Abstract：

Although　photothermal　therapy　(PTT)　is　preclinically　applied　in　solid　tumor　treatment,　incomplete　tumor　removal　of　PTT　and　heat　endurance　of　tumor　cells　induces　significant　tumor　relapse　after　treatment,　therefore　lowering　the　therapeutic　efficiency　of　PTT.　Herein,　a　programmable　therapeutic　strategy　that　integrates　photothermal　therapeutic　agents　(PTAs),　DNAzymes,　and　artificial　engineered　natural　killer　(A-NK)　cells　for　immunotherapy　of　hepatocellular　carcinoma　(HCC)　is　designed.　The　novel　PTAs,　termed　as　Mn-CONASHs,　with　2D　structure　are　synthesized　by　the　coordination　of　tetrahydroxyanthraquinone　and　Mn2+　ions.　By　further　adsorbing　polyetherimide/DNAzymes　on　the　surface,　the　DNAzymes@Mn-CONASHs　exhibit　excellent　light-to-heat　conversion　ability,　tumor　microenvironment　enhanced　T1-MRI　guiding　ability,　and　antiheat　endurance　ability.　Furthermore,　the　artificial　engineered　NK　cells　with　HCC　specific　targeting　TLS11a-aptamer　decoration　are　constructed　for　specifically　eliminating　any　possible　residual　tumor　cells　after　PTT,　to　systematically　enhance　the　therapeutic　efficacy　of　PTT　and　avoid　tumor　relapse.　Taken　together,　the　potential　of　A-NK　cells　combined　with　antiheat　endurance　as　a　powerful　strategy　for　immuno-enhancing　photothermal　therapy　efficiency　of　solid　tumors　is　highlighted,　and　the　current　strategy　might　provide　promising　prospects　for　cancer　therapy.　©　2019　WILEY-VCH　Verlag　GmbH　&　Co.　KGaA,　Weinheim

Keyword：

antiheat endurance; artificial natural killer cells; coordination nanosheets; DNAzymes; immunotherapy; phototherapy

Community：

[ 1 ] [Zhang, D.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 2 ] [Zhang, D.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 3 ] [Zhang, D.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 4 ] [Zhang, D.]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
[ 5 ] [Zheng, Y.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 6 ] [Zheng, Y.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 7 ] [Lin, Z.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 8 ] [Lin, Z.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 9 ] [Lan, S.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 10 ] [Lan, S.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 11 ] [Zhang, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 12 ] [Zhang, X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 13 ] [Zhang, X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 14 ] [Zheng, A.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 15 ] [Zheng, A.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 16 ] [Zheng, A.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 17 ] [Li, J.]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
[ 18 ] [Liu, G.]Center for Molecular Imaging and Translational Medicine, Xiamen University, Xiamen, 361005, China
[ 19 ] [Yang, H.]The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, 350002, China
[ 20 ] [Liu, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 21 ] [Liu, X.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 22 ] [Liu, X.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 23 ] [Liu, J.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, China
[ 24 ] [Liu, J.]The Liver Center of Fujian Province, Fujian Medical University, Fuzhou, 350025, China
[ 25 ] [Liu, J.]Mengchao Med-X Center, Fuzhou University, Fuzhou, 350116, China
[ 26 ] [Liu, J.]Liver Disease Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China

Reprint 's Address：

[Liu, X.]The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical UniversityChina

Email：

xiaoloong.liu@gmail.com

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ISSN： 1613-6810

Year： 2019

Issue： 42

Volume： 15

1 1 . 4 5 9

JCR@2019

1 3 . 0 0 0

JCR@2023

ESI HC Threshold：236

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count： 61

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

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