A　systematic　approach　for　designing　an　energy-saving　and　environmentally　friendly　pressure　swing　distillation　(PSD)　process　for　separating　binary　azeotropes　is　proposed　and　involves　the　initial　determination　of　the　operating　pressure　and　separating　sequence　based　on　the　temperature-composition　(T-xy)　diagram,　optimization　by　the　two-step　optimization　procedure　via　minimizing　the　lifetime　total　cost　(LTC),　heat　integration　(HI),　and　a　heat　pump　to　achieve　further　energy　savings　and　increase　the　process　sustainability.　The　Eco-indicator　99　(EI99)　is　first　introduced　as　an　assessment　criterion　to　evaluate　the　damage　to　the　environment　and　sustainability　of　the　PSD　process.　The　partial　and　full　HI-PSD　processes　are　studied,　and　their　corresponding　T-H　diagrams　are　provided　to　evaluate　the　feasibility　and　degree　of　heat　integration.　Three　HP-PSD　processes　are　investigated　and　optimized　by　minimizing　the　LTC.　The　results　show　that　compared　with　the　literature　design,　our　conventional　PSD　process　reduces　the　LTC　and　EI99　by　43.42%　and　47.86%.　The　partial　HI-PSD　processes　could　further　decrease　the　LTC　and　EI99　by　20.71%　and　27.19%　compared　with　the　conventional　PSD　process.　Meanwhile,　the　full　HP-PSD　process　could　reduce　the　LTC　and　EI99　by　14.12%　and　68.77%　compared　to　the　partial　HI-PSD　process.　Hence,　the　full　HP-PSD　process　is　the　most　favorable　from　both　economic　and　sustainability　perspectives.　Copyright　©　2019　American　Chemical　Society.