Facilitated　endogenous　tissue　engineering　is　emerging　as　a　convenient　and　easy　strategy　for　bone　repair.　However,　the　substitution　with　satisfactory　bioactivity　and　osteoinductivity　which　can　activate　endogenous　stem　cells　responds　and　in　situ　recruit　them　homing　towards　to　damaged　area　remains　a　challenge.　To　stimulate　the　biomineralization　process　of　inorganic　nanoparticles　in　natural　bone,　bioactive　nano　hydroxyapatite　particles　(nHAP)　were　in　situ　crystallized　into　the　graphene　oxide/chitosan/nHAP　(GO/CS/nHAP)　scaffold　via　effective　regulation　of　CS　functionalized　with　GO　network　matrix　and　presented　a　uniform　dispersion　with　nanometer-scale.　As-prepared　scaffold　exhibited　better　physicochemical　properties,　such　as　three-dimensional　(3D)　porous　bone-like　hierarchical　structure,　proper　mechanical　property,　biodegradation　as　well　as　suitable　water　uptake　and　retention　ratio.　The　biomimetic　mineralization　and　cell　culture　experiments　demonstrated　that　hybrid　scaffold　possessed　superior　bioactivity　and　cell　proliferation　ability　in　vitro.　In　addition,　the　rat　calvarial　defect　repair　models　and　tissue　pathological　characterization　further　proved　that　the　hybrid　scaffold　had　excellent　biocompatibility　and　capacity　of　in　situ　inducing　bone　regeneration.　Herein,　the　prepared　scaffold　might　be　an　excellent　candidate　for　endogenous　bone　repair.　©　2019　Elsevier　B.V.