The　Pt/CoSn(OH)6　and　Pt/ZnSn(OH)6　complex　catalysts　were　prepared　using　CoSn(OH)6　and　ZnSn(OH)6　hollow　nanocubes　by　an　ultrasound　process　with　ascorbic　acid　as　the　soft　reductant,　respectively,　and　demonstrate　excellent　performance　towards　the　methanol　oxidation　reaction　(MOR).　The　Pt/CoSn(OH)6　and　Pt/ZnSn(OH)6　catalysts　exhibit　higher　mass　activities　(1095.6　mA/mg　and　699.5　mA/mg,　respectively)　compared　to　Pt/C　(594.6　mA/mg)　catalyst　towards　methanol　oxidation.　XRD,　SEM,　TEM,　XPS　and　electrochemical　measurements　were　employed　to　explore　the　relationships　of　the　crystal　structure　and　the　properties　of　catalysts.　CO-stripping　experiment　results　indicate　that　the　hydroxide　supports　facilitates　the　removal　of　CO　on　Pt　surface.　The　increased　activity　and　resistance　of　CO　poisoning　for　Pt/CoSn(OH)6　and　Pt/ZnSn(OH)6　catalysts　can　be　attributed　to　the　strong　interaction　between　the　support　(Co,　Zn)Sn(OH)6　and　Pt　in　the　catalysts　and　the　large　amount　of　hydroxyls　on　the　support　surface.　The　higher　relative　intensity　of　Pt　in　the　(Co,　Zn)Sn(OH)6　catalysts　also　contributes　to　the　higher　MOR　activity.　The　(Co,　Zn)Sn(OH)6　towards　methanol　catalytic　electro-oxidation　can　disclose　the　influence　of　the　support　structure　on　the　catalytic　activity　and　will　be　helpful　for　the　development　and　application　of　complex　catalysts　in　direct　methanol　fuel　cells　(DMFCs).　©　2018,　Editorial　Office　of　Acta　Materiae　Compositae　Sinica.　All　right　reserved.