In　order　to　solve　the　problems　of　video　scintillation,　charge　leakage　and　achieving　dynamic　multi-grayscale　display　on　electrowetting　electronic　paper　displays,　a　set　of　driving　system　was　designed　for　the　study　of　electrowetting　electronic　paper　displays.　First　of　all,　this　paper　proposes　a　driving　system　architecture　of　embedded　platform　+　FPGA　based　on　the　functions　that　the　complete　electrowetting　electronic　paper　drive　system　must　have,　in　which　the　embedded　platform　can　carry　out　real-time　image　processing　on　the　video　source.　And　the　corresponding　timing　control　will　be　achieved　by　FPGA　according　to　the　received　processed　data.　Next,　the　source　gate　driver　chip　of　the　existing　electrophoresis　electronic　paper　is　used　as　the　driver　chip　of　the　electrowetting　electronic　paper.　Finally,　this　paper　proposes　the　concepts　of　unequal　subframes　and　reset　frames　to　solve　the　problem　of　video　flicker　and　charge　leakage　so　as　to　achieve　a　better　multi　gray　scale　display.　The　experimental　results　show　that　the　drive　system　successfully　solves　the　problems　of　electrowetting　video　flicker,　charge　leakage　and　multi-grayscale　display　problems.　The　video　refresh　rate　of　the　electrowetting　electronic　paper　reaches　to　30　Hz,　the　maximum　gray　level　of　the　pixel　can　reach　16　gray　scale　and　the　reflectivity　is　close　to　60%　at　the　highest　gray　level.　The　whole　drive　system　basically　meets　the　dynamic　display　of　multi　grayscale.　©　2018,　Science　Press.　All　rights　reserved.