In　order　to　explore　the　impact　of　auxiliary　hypoglycemic　of　superoxide　dismutase　(SOD)　by　Maillard　reaction,　based　on　bovine　blood　SOD　as　raw　material,　added　glucose　for　non-enzymatic　glycation　reaction,　the　glycated　SOD　(SOD-G)　and　single　bovine　blood　SOD　were　used　to　treat　alloxan-induced　diabetic　rats,　to　compare　the　effect　of　weight,　blood　glucose,　oral　glucose　tolerance,　the　SOD　levels　of　tissue　organs　(Heart,　liver,　kidney,　pancreas　and　skeletal　muscle)　and　the　level　of　plasma　insulin　(INS),　amp　activated　protein　kinase　(AMPK)　and　malondialdehyde　(MDA)　of　diabetic　rats　given　SOD　and　an　equal　dose　of　SOD-G,　as　well　as　different　doses　of　SOD-G.　The　test　results　show　that　SOD-G　and　SOD　have　a　significant　effect　on　reduction　of　blood　glucose　in　alloxan-induced　type　I　diabetic　rats,　but　each　has　its　advantages.　There　are　no　differences　in　body　weight　control.　SOD-G　hypoglycemic　effect　is　significantly　better　than　SOD　(P＜0.05),　while　in　the　OGTT　test,　the　effect　of　SOD　on　glucose　tolerance　damage　is　significantly　better　than　SOD-G　(P＜0.05).　In　tissue　SOD　level　test,　both　of　them　increase　the　content　of　SOD　in　the　pancreas,　and　have　no　significant　effect　on　the　SOD　content　in　skeletal　muscle　and　heart,　and　SOD　level　of　liver　and　kidney　in　SOD-G　group　is　significantly　lower　than　that　in　SOD　group,　There　are　no　significant　difference　in　INS,　AMPK,　and　MDA　levels.These　results　indicate　that　superoxide　dismutase,　in　the　wake　of　the　Maillard　reaction　modification,　still　has　obvious　auxiliary　hypoglycemic　effect,　and　the　overall　effect　of　SOD-G　is　better　than　SOD.　But　maybe　due　to　the　Maillard　reaction　modification　its　structure　changes,　and　SOD-G　and　SOD　in　vivo　absorption　way　changes,　there　are　some　differences　in　the　final　treatment　effect.　©　2018,　Editorial　Office　of　Journal　of　CIFST.　All　right　reserved.