Prior　research　has　indicated　that　as　an　important　biomarker　of　chronic　low-grade　inflammation,　high-sensitivity　C-reactive　protein　(hs-CRP)　can　play　important　roles　on　the　onset　of　metabolic　syndrome　and　cardiovascular　diseases　(CVD).　We　conducted　an　integrative　approach,　which　combines　biological　wet-lab　experiments,　statistical　analysis,　and　semantics-oriented　bioinformatics　&　computational　analysis,　to　investigate　the　association　among　hs-CRP,　body　fat　mass　(FM)　distribution,　and　other　cardiometabolic　risk　factors　in　young　healthy　women.　Research　outcomes　in　this　study　resulted　in　two　novel　discoveries.　Discovery　1:　There　are　four　primary　determinants　for　hs-CRP,　i.e.,　central/abdominal　FM　(a.k.a.　trunk　FM)　accumulation,　leptin,　high　density　lipoprotein　cholesterol　(HDL-C),　and　plasminogen　activator　inhibitior-1　(PAI-1).　Discovery　2:　Chronic　inflammation　may　involve　in　adipocyte-cytokine　interaction　underlying　the　metabolic　derangement　in　healthy　young　women.　©　2018　Elsevier　Inc.