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author：

Chen, J. (Chen, J..) [1] | Fang, Y. (Fang, Y..) [2] | Liu, H. (Liu, H..) [3] | Chen, N. (Chen, N..) [4] | Chen, S. (Chen, S..) [5] | Xue, J. (Xue, J..) [6]

Indexed by：

Scopus

Abstract：

Photodynamic　therapy　(PDT)　is　an　innovative　and　promising　modality　to　treat　various　tumors.　In　this　study,　two　novel　zinc(II)　phthalocyanines　substituted　with　quinolin-8-yloxy　groups　at　the　α-position,　namely　mono(quinolin-8-yloxy)　zinc(II)　phthalocyanine　(ZnPc-Q1)　and　tetra(quinolin-8-yloxy)　zinc(II)　phthalocyanine　(ZnPc-Q4),　have　been　synthesized　and　fully　characterized.　With　quinolin-8-yloxy,　these　two　phthalocyanines　exhibit　less　self-aggregation　in　DMF　and　culture　medium,　high　singlet　oxygen　quantum　yields,　mitochondria　localization　and　high　photodynamic　activities　(IC50　values　as　low　as　2　nM).　Compared　to　ZnPc-Q4,　ZnPc-Q1　exhibits　higher　cellular　uptake　and　lower　IC50　values.　Benefitting　from　its　higher　anticancer　efficacy　and　lack　of　isomers,　ZnPc-Q1　is　a　highly　promising　anticancer　agent　in　clinical　application.　©　2018　World　Scientific　Publishing　Company.

Keyword：

photodynamic therapy; phthalocyanine; quinolin-8-yloxy

Community：

  • [ 1 ] [Chen, J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian Engineering Research Center for Photodynamic Therapy and Diagnoses, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 2 ] [Fang, Y.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian Engineering Research Center for Photodynamic Therapy and Diagnoses, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 3 ] [Liu, H.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian Engineering Research Center for Photodynamic Therapy and Diagnoses, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 4 ] [Chen, N.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian Engineering Research Center for Photodynamic Therapy and Diagnoses, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China
  • [ 5 ] [Chen, S.]Dermatological Department, Fuzhou General Hospital PLA., Fuzhou, Fujian, China
  • [ 6 ] [Xue, J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian Engineering Research Center for Photodynamic Therapy and Diagnoses, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China

Reprint 's Address：

  • [Xue, J.]National and Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, Fujian Engineering Research Center for Photodynamic Therapy and Diagnoses, College of Chemistry, Fuzhou UniversityChina

Email：


xuejinping66@fzu.edu.cn
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Source ：

Journal of Porphyrins and Phthalocyanines

ISSN： 1088-4246

Year： 2018

Issue： 9-10

Volume： 22

Page： 807-813

1 . 2 9 2

JCR@2018

0 . 9 0 0

JCR@2023

ESI HC Threshold：209

JCR Journal Grade：3

CAS Journal Grade：4

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 1

Affiliated Colleges：

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