A　copper　metal-organic　framework　(MOF)　compound　based　on　2,5-thiophenedi-carboxylic　acid　(H2TDC)　ligand,　namely　Cu(TDC)(H2O)·DMA　(1,　DMA　=　N,N΄-dimethylace-tamide),　has　been　synthesized　in　gram-scale　via　a　one-pot　solvothermal　route　in　a　high　yield　of　81.3%.　Single-crystal　X-ray　analysis　reveals　that　the　structure　of　1　features　a　three-dimensional　(3D)　open　framework　constructed　by　TDC　interconnecting　1D　chains　of　[-Cu(COO)(H2O)Cu-]n.　Thermal　property　was　investigated　by　TG-MS.　The　magnetic　measurements　indicate　the　existence　of　weak　antiferromagnetic　interactions　between　the　Cu2+　centers　in　1.　©　2018　Fujian　Institute　of　Research　of　the　Structure　of　Matter.　All　Rights　Reserved.