In　this　work,　we　combined　superwettable　micropattern　with　electrochemical　deposition　to　produce　titanium　sheet　with　Raman　detection　hot　spots　surface-enhanced　Raman　scattering　(SERS).　After　thiol　treatment　and　UV　irradiation,　the　surface　quickly　changes　to　superhydrophilic　state.　The　wettability　of　solid　surface　is　greatly　depending　on　the　chemical　composition　and　the　geometric　structure　of　the　surface.　Base　on　the　micropatterning　template　with　highly　contrast　of　wettability,　dendrite-like　silver　crystals　selective　coated　on　the　superhydrophilic　regions　possess　a　highly　ultra-sensitivity　for　molecular　detecting.　This　composite　platform　can　achieve　ultra-sensitive　detection　of　chemical　and　biological　molecules,　can　be　used　for　analytical　chemistry,　molecular　diagnostics,　and　environmental　monitoring,　and　has　a　wide　range　of　application　prospects.　©　2018　Elsevier　Ltd