The　lamellar　structure　and　fracture　behavior　of　a　γ-based　Ti-48A1-2Mn-2Nb　(at.%)　alloy　produced　by　centrifugal　spray　deposition　(CSD)　processing　have　been　systematically　investigated.　The　results　show　that　the　formation　of　the　lamellar　structure　observed　with　scanning　electron　microscopy　(SEM)　results　from　the　dendrite　segregation　during　rapid　solidification,　and　the　lath　structure　revealed　by　transmission　electron　microscopy　(TEM)　stems　from　phase　transformation　under　α-transus　temperature.　The　CSD　processing　provides　finer　lamellar　colonies　in　γ-titanium　aluminide,　and　as　a　consequense,　moderate　ductility　with　appropriate　fracture　toughness　can　be　achieved.　Based　on　the　experimental　observations,　the　toughening　mechanisms　in　the　CSD　Ti-48Al-2Mn-2Nb　alloy　are　discussed.