In　order　to　ensure　the　safe　operation　of　the　bridge,　it　is　very　necessary　to　establish　real-time　monitoring　system　on　some　extraordinary　large-scale　bridges.　In　this　paper,　the　prestressed　concrete　continuous　bealm　bridge　is　taken　as　the　research　object.　Firstly,　ANSYS　is　used　to　establish　the　initial　finite　element　model　according　to　the　design　data　of　the　bridge,　and　then　update　the　calculation　model　to　conform　to　the　actual　state　of　the　structure.　After　that,　the　analysis　of　mechanical　performance　under　design　load　is　carried　out　to　provide　a　theoretical　basis　for　the　optimal　placement　of　sensors.　Finally,　the　bridge　real-time　monitoring　system　is　set　up　and　the　collected　monitoring　data　(displacement,　strain,　acceleration,　etc.)　is　taken　a　statistical　analysis,　for　the　purpose　of　making　a　preliminary　judgement　on　the　actual　operation　of　the　bridge,　and　being　considered　as　the　theoretical　basis　and　database　of　real-time　monitoring　system　for　follow-up　study.　©　Published　under　licence　by　IOP　Publishing　Ltd.