This　paper　describes　the　studies　on　methods　of　compression　for　medical　echocardiography　sequence,　or　called　ultrasound　sequential　images　in　this　paper.　The　aim　is　to　find　a　combination　of　methods,　which　achieves　the　highest　overall　compression　performance.　Our　approach　is　based　on　region　of　interest　(ROI),　i.e.　to　segment　the　image　into　several　regions　according　to　their　spatial　characteristics,　and　then　compress　them　separately　with　different　methods.　In　doing　so,　we　are　able　to　achieve　a　relatively　high　compression　ratio　of　about　7.2　white　preserving　the　lossless　contents　of　important　regions.