This　paper　presents　some　methods　of　medical　image　retrieval　technique　based　on　extraction　of　region　of　interest.　First　of　all,　in　order　to　extract　the　focus　region　about　medical,　we　propose　a　middle-value　filtering　idea　combined　region　growing　and　mathematical　morphology　operator.　Then　based　on　the　idea　above,　we　present　two　methods　of　interest　extraction.　One　is　the　T-Sobel　edge　detection　method　that　is　combined　thresholdbased　segmentation　and　Sobel　operator.　The　other　is　based　on　a　method　of　fuzzy　c-means　and　region　growing,　which　is　called　FCM-Region.　At　last,　we　compare　these　approaches　with　the　method　of　retrieval　based　on　medical　features　and　make　a　detailed　analysis　in　which　the　result　indicates　that　the　method　discussed　in　this　paper　is　much　more　effective.　©　2010　IEEE.