Theoretical　and　experimental　investigation　(ambient　vibration　tests　and　permanent　monitoring　system)　on　the　structural　behavior　of　a　curved　cable-stayed　bridge　is　presented　in　the　paper.　The　investigated　bridge　-　erected　in　the　Commercial　Harbor　of　Marghera　(Venice,　Italy)　-　was　opened　to　traffic　on　January　2007　and　includes　six　generally　curved　spans,　where　the　two　main　(105　m　+　126　m)　spans　are　suspended　by　cable-stays,　connected　to　the　centerline　of　the　deck.　As　a　consequence　of　the　spatial　structural　arrangement,　the　dynamic　behavior　of　the　deck　appears　very　complex　in　both　bending　and　torsion.　In　this　paper,　based　on　the　experimental　dynamic　tests　on　a　curved　cable-stayed　bridge　carried　out　during　construction　phase　in　May　2006　and　during　public　service　in　July　2010,　finite　element　model　was　built　and　tuned　accurately　according　to　comparisons　between　experimental　and　theoretical　analyses.　Then,　analyses　were　performed　to　investigate　the　applicability　of　monitoring　techniques　on　the　modal　parameters,　deformation,　stress,　and　strain.　In　the　end,　suggestions　and　recommendations　on　the　bridge　monitoring　system　were　discussed　and　presented.　©　2012　Taylor　&　Francis　Group.