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author:

Zhou, Xiangdong (Zhou, Xiangdong.) [1] (Scholars:周向东) | Chan, Keith C. C. (Chan, Keith C. C..) [2] | Zhu, Danhong (Zhu, Danhong.) [3]

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Abstract:

Multiple correlated phenotypes often appear in complex traits or complex diseases. These correlated phenotypes are useful in identifying gene-gene interactions associated with complex traits or complex disease more effectively. Some approaches have been proposed to use correlation among multiple phenotypes to identify gene-gene interactions that are common to multiple phenotypes. However these approaches either didn't find truly gene-gene interactions or got results which are hard to explain, especially by using all correlated phenotypes to identify gene-gene interactions, they made identified interactions unreliable. In this paper, we propose Multivariate Quantitative trait based Ordinal MDR (MQOMDR) algorithm to effectively identify gene-gene interactions associated with multiple correlated phenotypes by selecting the best classifier according to not only the training accuracy of the phenotype under consideration but also other phenotypes with weights determined mainly by their pair correlation with the phenotype under consideration and also by repeated selection process to make use of truly useful correlated phenotypes. Experimental results on two real datasets show that our algorithm has better performance in identifying gene-gene interactions associated with multiple correlated phenotypes. © 2017 IEEE.

Keyword:

Artificial intelligence Bioinformatics Genes

Community:

  • [ 1 ] [Zhou, Xiangdong]Dept. of Computing, Hong Kong Polytechnic University, Hong Kong, Hong Kong
  • [ 2 ] [Zhou, Xiangdong]College of Mathematics and Computer Science, Fuzhou University, Fujian, China
  • [ 3 ] [Chan, Keith C. C.]Dept. of Computing, Hong Kong Polytechnic University, Hong Kong, Hong Kong
  • [ 4 ] [Zhu, Danhong]College of Mathematics and Computer Science, Fuzhou University, Fujian, China

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Year: 2017

Language: English

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SCOPUS Cited Count: 1

ESI Highly Cited Papers on the List: 0 Unfold All

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30 Days PV: 1

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