A　current　feedback　instrumentation　amplifier　(CFIA)　for　electrocardiogram　(ECG)　acquisition　systems　is　proposed　in　this　paper.　In　order　to　reduce　the　electrode　offset　(EOS)　and　baseline　drift,　an　electrode　offset　cancellation　module　is　used.　Right　leg　drive　(RLD)　module　is　added　to　improve　the　common　mode　rejection　ratio　(CMRR),　suppress　common　mode　interference.　An　operational　transconductance　amplifier-capacitor　(OTA-C)　low-pass　filter　is　integrated　at　the　output　of　the　CFIA　to　filter　out　high-frequency　noise　caused　by　the　ambient　environment.　The　circuit　is　designed　and　simulated　using　a　0.18　μm　CMOS　process.　The　circuit　operates　at　2V　and　consumes　a　total　current　of　47μA.　Simulation　results　show　that　the　CMRR　of　the　circuit　can　reach　129dB,　and　the　canceled　electrode　offset　voltage　is　±200mV.　©　2018　IEEE.