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Abstract:
Noncoding RNAs (ncRNAs) regulate gene expression in essential cellular processes and play key roles in many human diseases. Small nucleolar RNAs (snoRNAs) are a relatively large group of ncRNAs. Many studies have identified significant alterations of different snoRNAs in prostate, breast, and lung malignancies and that many of these snoRNAs have been shown to be processed into microRNA-like molecules known as snoRNA-derived RNAs (sdRNAs). Similarly, several small RNAs have also recently been found to be excised from well characterized tRNAs to function in both normal cellular metabolism and disease. In this paper, we present a new computational methodology for the identification, analysis, and visualization of ncRNA-derived RNAs (ndRNAs) with linear time and space complexity (named SURFr for Short Uncharacterized R NA Finder). We provide the results of our algorithm's running time by analyzing several publicly available datasets and finally discuss future research directions to our work. © 2019 IEEE.
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Year: 2019
Page: 1504-1507
Language: English
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WoS CC Cited Count: 0
SCOPUS Cited Count: 3
ESI Highly Cited Papers on the List: 0 Unfold All
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30 Days PV: 2
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