A　nonautonomous　multi-species　predator-prey　system　with　feedback　controls　is　proposed　in　this　paper,　where　the　competition　among　the　predator　species　and　among　the　prey　species　is　considered,　also　some　important　factors　such　as　the　effect　of　toxins　and　the　age-structure　are　also　considered.　Average　conditions　are　obtained　for　permanence　and　global　attractivity　in　the　system.　The　results　obtained　here　generalized　the　main　results　of　Zhao　and　Jiang　[J.D.　Zhao,　J.F.　Jiang,　Permanence　in　nonautonomous　Lotka-Volterra　system　with　predator-prey,　Appl.　Math.　Computat.,152　(2004)　99-109].　©　2005　Elsevier　Inc.　All　rights　reserved.