A　simple　and　convenient　end-column　chemiluminescence　(CL)　detection　coupled　to　pressurized　capillary　electrochromatography　(pCEC)　was　described.　Luminol　and　N-(4-aminobutyl)-N-ethylisoluminol　(ABEI)　were　adopted　as　mode　compounds　to　evaluate　the　feasibility　of　end-column　reactor.　Detailed　analysis　of　ABEI　revealed　that　the　high　sensitivity　could　be　obtained　with　the　reactor.　Furthermore,　determination　of　norepinephrine　(NE)　and　epinephrine　(EP),　which　were　labeled　with　ABEI,　was　accomplished　by　using　the　end-column　pCEC-CL　detection　based　on　ABEI-potassium　ferricyanide-alkaline　medium　CL　reaction　system.　Under　the　optimum　conditions,　the　detection　limit　(S/N　=　3)　of　NE　and　EP　was　0.08　μM　and　0.06　μM,　respectively.　The　proposed　method　has　also　been　successfully　applied　to　the　analysis　of　adrenaline　hydrochloride　injection　sample.　©　2007　Elsevier　B.V.　All　rights　reserved.