Based　on　the　engineering　background　of　the　Guanhe　Bridge,　a　composite　cable-stayed　bridge,　the　accurate　finite　element　(FE)　model　and　the　multi-scale　finite　element　(MFE)　model　was　established.　The　actual　dynamic　characteristics　is　obtained　based　on　the　visual　inspection　and　ambient　vibration　testing.　Then　based　on　two-phase　response　surface　methods,　the　error　between　the　MFE　model　and　the　accurate　FE　model　will　be　updated　firstly,　and　the　error　between　the　updated　MFE　model　and　the　bridge　will　be　updated　later　and　the　results　between　the　updated　model　and　the　measurements.　It　can　be　concluded　that　the　results　from　the　updated　MFE　model　based　on　the　two-phase　response　surface　methods　are　in　good　agreement　with　the　measurements,　with　the　maximum　error　is　less　than　8%　and　the　values　of　MAC　being　above　90%.　Which　above　that　the　two-phase　response　surface　methods　are　suitable　for　MFE　model　updating,　and　the　parameters　of　the　MFE　model　still　keep　their　physical　significance　after　updating.　It　can　be　used　to　multi-scale　damage　detection　and　multi-scale　damage　prognosis,　and　employed　for　bridge　health　monitoring　and　safety　evaluation.