A　method　is　proposed　to　calculate　seismic　probabilistic　risk　considering　the　randomness　of　the　material　and　the　seismic　wave,　and　the　seismic　hazard.　It　avoids　the　cumbersome　integration　simultaneously.　Based　on　the　probability　distribution　of　the　structural　material　parameters,　a　method　of　Latin　Hypercube　Sampling　(LHS)　is　adopted　to　consider　the　randomness　of　the　material　parameters　of　the　structural　members.　A　sample　set　of　ground　motion　-　bridge　combination　is　formed　according　to　the　selected　seismic　waves.　A　nonlinear　finite　element　fiber　model　for　the　typical　short-tower　cable-stayed　structural　system　is　established.　The　damage　index　of　the　key　components　is　identified.　The　seismic　fragility　analysis　of　lower-tower　cable-stayed　bridge　is　carried　out　with　incremental　dynamic　analysis　(IDA),　and　the　PGA-structural　damage　probability　function　is　fitted.　Monte　Carlo　sampling　methods　is　used　for　discretion　of　seismic　hazard　probability　functions,　which　avoids　the　cumbersome　integration.　The　seismic　probabilistic　risk　assessment　is　made　for　a　typical　lower-tower　cable-stayed　bridge.