A　silica-UIO-66　composite　was　fabricated　by　a　simple　hydrothermal　method　and　then　applied　as　liquid　chromatographic　stationary　phase　for　fast　and　efficient　separation.　X-ray　diffraction　patterns　showed　the　presence　of　UIO-66　crystals　in　the　silica-UIO-66　composites;　while　scanning　electron　microscope　(SEM)　images　revealed　that　silica-UIO-66　composites　were　a　homogeneous　mixture　of　silica　bead　and　UIO-66　crystals.　A　variety　of　substituted　aromatics,　chlorobenzene　compounds　and　polycyclic　aromatic　hydrocarbons　(PAHs)　were　used　to　evaluate　the　retention　properties　of　the　silica-UIO-66　composite　packed　column.　Under　the　optimized　conditions,　baseline　separation　of　ethylbenzene　(EB)　and　styrene　was　obtained　with　high　resolution　and　short　retention　time.　In　addition,　the　silica-UIO-66　composite　packed　column　also　showed　some　advantages　in　separation　of　positional　isomers,　with　which　baseline　separation　of　EB　and　xylene,　chlorotoluene　and　dichlorobenzene　isomers　was　achieved.　Moreover,　the　retention　mechanisms　of　these　compounds　were　also　discussed　in　detail.　The　relative　standard　deviations　(RSDs)　for　the　separation　of　EB　and　xylene,　chlorotoluene　and　dichlorobenzene　isomers,　as　well　as　EB　and　styrene　were　0.42-0.9%,　1.0-1.9%,　0.75-2.0%,　and　0.9-2.1%　for　the　retention　time,　peak　area,　peak　height,　and　half　peak　width,　respectively.　The　column　efficiencies　for　EB,　p-chlorotoluene,　p-dichlorobenzene　and　styrene　were　8780,　9060,　9990　and　5130　plates/m.　The　successful　applications　suggested　high　potentials　of　silica-MOFs　composite　as　stationary　phase　for　fast　and　efficient　liquid　chromatography　separation.　©　2014　Elsevier　B.V.