The　solubility　of　cefpiramide　sodium　in　binary　solvent　mixtures　of　ethanol　+　water　and　2-propanol　+　water　was　determined　by　a　steady-state　method　from　(278.2　to　303.2)　K　and　in　the　initial　mole　fraction　range　of　alcohol　(ethanol　or　2-propanol)　in　the　solvent　mixture　at　about　0.4　to　0.8.　Cefpiramide　sodium　exhibits　the　same　order　of　magnitude　of　solubility　in　both　binary　systems.　The　solubility　decreases　with　the　increase　of　the　initial　mole　fraction　of　alcohol　and　increases　with　increasing　temperature.　Dilution　crystallization　or　dilution　crystallization　incorporated　with　cooling　crystallization　will　be　more　suitable　than　pure　cooling　crystallization　for　the　purification　of　cefpiramide　sodium.　The　Jouyban-Acree　model,　combined　with　the　van＇t　Hoff　equation,　was　used　to　correlate　the　solubility　data.　The　combined　model　was　further　simplified　so　that　each　item　in　the　model　is　statistically　significant　at　the　5　%　level.　The　simplified　combined　model　gives　a　mean　relative　deviation　of　5.3　%　for　the　ethanol　+　water　system,　and　3.0　%　for　the　2-propanol　+　water　system.　This　model　demonstrates　good　fitting　with　the　experimental　solubility　data,　and　could　be　used　for　related　process　design　in　the　pharmaceutical　industry.　©　2013　American　Chemical　Society.