The　existing　literature　about　technological　innovation　generally　ignored　the　problem　of　the　spatial　spillover　effects　of　R&D　investment　and　nonlinear　relationship　between　environmental　regulation　and　technological　innovation.　This　paper　use　the　semi-parametric　spatial　lag　model　explains　these　two　issues　empirically.　The　results　are　as　follows:　(1)　The　development　of　R&D　investment　and　its　spatial　spillover　effects　promote　china　regional　technological　innovation.　(2)　Environmental　regulation　has　different　effects　on　technological　innovation　in　different　regions.　Low　environmental　regulation　restrains　the　development　of　technological　innovation,　and　high　environmental　regulation　promotes　the　development　of　technological　innovation.　Especially　in　the　central　area　of　china　where　environmental　pollution　is　serious　the　effect　is　particularly　evident.　For　most　areas　like　Fujian　and　Guangdong　where　environmental　regulation　is　moderate,　environmental　regulation　has　low　impact　on　technological　innovation.　These　areas　need　to　further　enhance　the　intensity　environmental　regulation.　©　Sila　Science.　All　Rights　Reserved.