It　is　of　great　scientific　and　practical　significance　to　explore　inorganic　mimetic　enzymes　to　replace　natural　enzymes　due　to　their　instability　and　high　cost.　Herein　we　present　an　interesting　discovery　that　a　V2O3-ordered　mesoporous　carbon　composite　(V2O3-OMC)　has　a　novel　peroxidase-like　activity　towards　fast　redox　reaction　of　typical　peroxidase　substrates　H2O2　and　2,2′-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic　acid)　diammonium　salt　(ABTS).　Due　to　the　small　size　effect　and　large　surface　area　of　V2O3　nanoparticles　supported　by　OMC,　V2O3-OMC　exhibited　excellent　catalytic　performance　with　a　kcat　of　1.28　×　104　s-1,　KM　(ABTS)　of　0.067　mM　and　KM　(H2O2)　of　0.16　mM,　and　a　significantly　higher　catalytic　efficiency　(kcat/KM)　towards　the　oxidation　of　ABTS　in　comparison　with　the　natural　peroxidases.　Furthermore,　the　Ping-pong　BiBi　mechanism　was　proposed　to　explain　the　catalytic　reaction　by　V2O3-OMC.　Based　on　this　highly　active　biomimetic　peroxidase　and　the　colorimetric　detection　of　H2O2,　a　facile　analytical　method　was　developed　to　detect　glucose　by　using　V2O3-OMC　and　glucose　oxidase,　which　had　a　wide　linear　range　(0.01-4　mM　glucose),　good　selectivity　and　reliability　for　successful　detection　of　various　real　samples.　Thus,　the　novel　V2O3-OMC　peroxidase　mimetic　holds　great　promise　for　broad　potential　applications.　©　The　Royal　Society　of　Chemistry　2015.