In　this　study,　elastic　porous　polydimethylsiloxane　(PDMS)　cell　scaffolds　were　fabricated　by　vacuum-assisted　resin　transfer　moulding　(VARTM)　and　particle　leaching　technologies.　To　control　the　porous　morphology　and　porosity,　different　processing　parameters,　such　as　compression　load,　compression　time,　and　NaCl　particle　size　for　preparing　NaCl　preform,　were　studied.　The　porous　structures　of　PDMS　cell　scaffolds　were　characterized　by　scanning　electron　microscopy　(SEM).　The　properties　of　PDMS　cell　scaffolds,　including　porosity,　water　absorption,　interconnectivity,　compression　modulus,　and　compression　strength　were　also　investigated.　The　results　showed　that　after　the　porogen-NaCl　particles　had　been　leached,　the　remaining　pores　had　the　sizes　of　150-300,　300-450,　and　450-600　μm,　which　matched　the　sizes　of　the　NaCl　particles.　The　interconnectivity　of　PDMS　cell　scaffolds　increases　with　an　increase　in　the　size　of　NaCl　particles.　It　was　also　found　that　the　smaller　the　size　of　the　NaCl　particles,　the　higher　the　porosity　and　water　absorption　of　PDMS　cell　scaffolds.　The　content　of　residual　NaCl　in　PDMS/NaCl　scaffolds　reduces　under　ultrasonic　treatment.　In　addition,　PDMS　scaffolds　with　a　pore　size　of　300-450　μm　have　better　mechanical　properties　compared　to　those　with　pore　sizes　of　150-300　and　450-600　μm.　©　2015　Wiley　Periodicals,　Inc.　J.　Appl.　Polym.　Sci.　2016,　133,　42909.　©　2015　Wiley　Periodicals,　Inc.