Iodine-modified　TiO2(I-TiO2)　film　were　coated　on　medical-grade　PVC　material　by　impregnation-deposition　method　and　subsequently　characterized　by　XRD,　SEM,　TEM,　AFM,　DRS　and　XPS.　The　photocatalytic　anti-bacterial　activity　of　I-TiO2/PVC　was　investigated　both　by　in　vitro　anti-bacterial　experiments　and　by　clinical　study.　The　results　revealed　that　I-TiO2/PVC　exhibit　excellent　photocatalytic　antibacterial　activity,　which　can　destroy　the　propagation　of　the　Escherichia　coli　and　cause　the　deactivation　and　death　of　most　E.　coli　bacteria　within　30　min　visible　light　illumination.　Clinical　study　on　animals　showed　that　I-TiO2　coated　on　PVC　decrease　the　formation　of　biofilm　on　PVC　surface　in　the　mechanical　ventilation.　Furthermore,　I-TiO2/PVC　can　effectively　reduce　inflammation　of　tracheal　tissue　of　bam　suckling　pig　and　prevents　the　occurrence　of　VAP.　©　2016　Elsevier　B.V.