Prestressed　concrete-filled　steel　tube　(CFT)　truss　girders　usually　consist　of　CFT　chords,　hollow　steel　tube　braces,　and　high-strength　prestressing　strands.　This　paper　investigates　the　behavior　of　prestressed　CFT　truss　girders　by　conducting　both　experimental　tests　and　finite　element　analyses.　Experimental　tests　on　five　prestressed　CFT　truss　girders　are　first　conducted.　The　test　parameters　are　the　prestress　level　and　shear　span-to-depth　ratio.　Results　from　the　experimental　tests　indicate　that:　(i)　the　initial　flexural　stiffness　and　flexural　strength　of　prestressed　CFT　truss　girders　increase　as　the　prestress　level　or　shear-span-to-depth　ratio　increases,　and　(ii)　the　failure　modes　of　prestressed　CFT　truss　girders　are　influenced　by　the　prestress　level　and　shear　span-to-depth　ratio.　Finite　element　models,　which　were　developed　previously　by　the　authors　for　CFT　truss　girders,　are　then　modified　to　predict　the　behavior　of　prestressed　CFT　truss　girders.　Comparisons　with　experimental　load-deformation　responses　indicate　that　the　developed　finite　element　models　can　reasonably　predict　the　behavior　of　prestressed　CFT　truss　girders.　©　2017　Elsevier　Ltd