The　bead　beating　method　was　used　to　disrupt　the　lyophilized　and　wet　cells　of　Chlorella　sp..　The　kinetics　and　specific　energy　consumption　of　cell　disruption　were　investigated　in　order　to　determine　the　effect　of　the　degree　of　cell　disruption　(as　reflected　by　the　amount　of　released　chlorophyll)　on　carotenoid　extraction.　The　results　showed　that　the　first-order　dynamic　equation　could　well　describe　the　cell　disruption　process.　The　maximum　extraction　efficiencies　of　carotenoid　of　6.38　and　6.26　mg/g　were　obtained　when　the　percentage　disruption　of　lyophilized　and　wet　cells　were　70%and　90%,　respectively.　It　was　found　that　the　energy　consumption　required　for　disruption　of　wet　cells　was　higher　than　that　required　for　lyophilized　cells.　Consistent　results　were　observed　from　the　disruption　of　lyophilized　cells　in　the　concentration　range　of　40-160　g/L　and　carotenoid　extraction　using　the　same　specific　energy　consumption.　For　wet　cells　at　80　g/L,　higher　cell　disruption　and　carotenoid　extraction　efficiencies　could　be　obtained　even　at　lower　specific　energy　consumption.　The　results　of　this　study　can　provide　both　theoretical　and　experimental　evidence　for　the　cell　disruption　of　Chlorella　sp.,　and　the　development　and　utilization　of　its　effective　components.　©　2019,　China　Food　Publishing　Company.　All　right　reserved.