Due　to　the　metal　ion-centered　structural　features,　the　metal-organic　frameworks(MOFs)　and　their　derivatives　can　be　used　to　construct　heterogeneous　persulfate　catalytic　oxidation　system.　The　heterogeneous　persulfate　activated　process　with　low　energy　consumption　and　high　efficiency　has　a　good　application　prospect　in　water　treatment.　In　this　review,　the　activation　of　persulfate　by　MOFs　and　their　derivatives　to　degrade　refractory　organic　pollutants　including　organic　dyes,　environmental　endocrine　disruptors　and　antibiotics　in　aqueous　solution　were　systematically　presented.　The　effects　of　MOFs＇　and　MOFs　derivatives＇　structure　and　composition　on　the　catalytic　degradation　of　organic　pollutants　were　discussed.　It　was　demonstrated　that　the　rational　structure　design,　synthesis　strategy,　unsaturated　metal　active　sites　of　catalysts　and　active　species　in　the　catalytic　oxidation　system　played　a　critical　role　in　the　degradation　of　organic　pollutants.　Finally,　the　problems　existed　in　the　MOFs-based　heterogeneous　persulfate　activated　system　were　summarized　and　it　was　proposed　that　the　construction　of　a　new　high-efficiency　combined　activation　system　and　the　in-depth　mechanism　exploration　and　improvement　would　be　the　focus　of　future　research.　©　2019,　Chemical　Industry　Press.　All　right　reserved.