Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression - Details

author：

Indexed by：

Abstract：

Staphyloxanthin　(STX)　is　a　virulence　factor　produced　by　Staphylococcus　aureus　(S.　aureus)　including　methicillin-resistant　S.　aureus　(MRSA),　a　widely　distributed　Gram-positive　bacterium　related　to　several　clinical　human　infections.　We　herein　reported　that　Naftifine,　a　broad-spectrum　antifungal　agent,　plays　an　important　role　on　photodynamic　antimicrobial　therapy　(PACT)　for　S.　aureus.　STX　attenuated　the　PACT　effect　on　S.　aureus　in　a　dose-dependent　manner,　which　probably　due　to　its　biological　function　of　scavenging　reactive　oxygen　species　(ROS).　On　the　contrary,　the　sensitivity　of　S.　aureus　to　PACT　was　significantly　improved　after　an　incubation　with　Naftifine　(10　μM)　compared　with　that　of　S.　aureus　untreated　with　Naftifine.　The　reason　for　this　phenomenon　is　that　Naftifine　inhibits　STX　biosynthesis　and　improves　membrane　permeability.　Taken　together,　we　identified　STX　as　a　limiting　factor　of　PACT　in　S.　aureus.　Meanwhile,　we　found　that　the　combination　of　PACT　and　Naftifine,　an　inhibitor　of　STX　biosynthesis,　has　synergistic　antibacterial　effect　on　S.　aureus,　and　provide　a　new　way　for　the　rapid　and　efficient　treatment　of　S.　aureus　infection　without　drug　resistance.　©　2020　Elsevier　Ltd

Keyword：

Antifungal agents Bacteria Biochemistry Biosynthesis Chemotherapy Photodynamic therapy Photosensitizers Staphylococcus aureus

Community：

[ 1 ] [Sun, Jing]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 2 ] [Sun, Jing]Fujian Agriculture and Forestry University, Fuzhou; Fujian; 350002, China
[ 3 ] [Zhang, Yuxiang]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 4 ] [Zhang, Yuxiang]University of Chinese Academy of Sciences, Beijing; 100049, China
[ 5 ] [Su, Jianqiang]Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen; Fujian; 361021, China
[ 6 ] [Su, Jianqiang]University of Chinese Academy of Sciences, Beijing; 100049, China
[ 7 ] [Dai, Tao]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 8 ] [Dai, Tao]Fujian Agriculture and Forestry University, Fuzhou; Fujian; 350002, China
[ 9 ] [Chen, Jincan]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 10 ] [Chen, Jincan]University of Chinese Academy of Sciences, Beijing; 100049, China
[ 11 ] [Zhang, Lei]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 12 ] [Zhang, Lei]University of Chinese Academy of Sciences, Beijing; 100049, China
[ 13 ] [Wang, Huanhuan]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 14 ] [Wang, Huanhuan]Fujian Agriculture and Forestry University, Fuzhou; Fujian; 350002, China
[ 15 ] [Liu, Wenzhen]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 16 ] [Liu, Wenzhen]University of Chinese Academy of Sciences, Beijing; 100049, China
[ 17 ] [Huang, Mingdong]College of Chemistry, Fuzhou University, Fuzhou; Fujian; 350118, China
[ 18 ] [Chen, Zhuo]State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou; Fujian; 350002, China
[ 19 ] [Chen, Zhuo]University of Chinese Academy of Sciences, Beijing; 100049, China

Reprint 's Address：

[chen, zhuo]university of chinese academy of sciences, beijing; 100049, china;;[chen, zhuo]state key laboratory of structural chemistry, fujian institute of research on the structure of matter, chinese academy of sciences, fujian college, university of chinese academy of sciences, fuzhou; fujian; 350002, china

Email：

zchen@fjirsm.ac.cn

Show more details

Related Keywords：

Enhanced Synergistic Antibacterial Activity through a Smart Platform Based on UiO-66 Combined with Photodynamic Therapy and Chemotherapy
2020，LANGMUIR
Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression
2020，DYES AND PIGMENTS
Phthalocyanine-Assembled "One-For-Two" Nanoparticles for Combined Photodynamic-Photothermal Therapy of Multidrug-Resistant Bacteria
2022，ACS APPLIED MATERIALS & INTERFACES
Rapid killing of bacteria by a new type of photosensitizer
2017，APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Antimicrobial effects of photodynamic therapy with antiseptics on Staphylococcus aureus biofilm on titanium surface
2019，PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY

Source ：

Dyes and Pigments

ISSN： 0143-7208

Year： 2020

Volume： 179

4 . 8 8 9

JCR@2020

4 . 1 0 0

JCR@2023

ESI HC Threshold：160

JCR Journal Grade：1

CAS Journal Grade：1

Cited Count：

WoS CC Cited Count：

SCOPUS Cited Count：

ESI Highly Cited Papers on the List： 0 Unfold All

WanFang Cited Count：

Chinese Cited Count：

30 Days PV： 0

Affiliated Colleges：

Get Fulltext

DOI Library Discovery Baidu Scholar Search Engineering Village

Type
Departments

All Years Choose Year From to