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author:

Li, Xingshu (Li, Xingshu.) [1] | Park, Eun-Yeong (Park, Eun-Yeong.) [2] | Kang, Youngnam (Kang, Youngnam.) [3] | Kwon, Nahyun (Kwon, Nahyun.) [4] | Yang, Mengyao (Yang, Mengyao.) [5] | Lee, Seunghyun (Lee, Seunghyun.) [6] | Kim, Won Jong (Kim, Won Jong.) [7] | Kim, Chulhong (Kim, Chulhong.) [8] | Yoon, Juyoung (Yoon, Juyoung.) [9]

Indexed by:

EI

Abstract:

Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keyword:

Diagnosis Diseases Fluorescence quenching Gas generators Molecular oxygen Photoacoustic effect Supramolecular chemistry

Community:

  • [ 1 ] [Li, Xingshu]College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou; 350108, China
  • [ 2 ] [Park, Eun-Yeong]Department of Electrical Engineering and Creative IT Engineering, POSTECH, Pohang; 37673, Korea, Republic of
  • [ 3 ] [Kang, Youngnam]Department of Chemistry, Postech-Catholic Biomedical Engineering Institute, POSTECH, Pohang; 37673, Korea, Republic of
  • [ 4 ] [Kwon, Nahyun]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of
  • [ 5 ] [Yang, Mengyao]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of
  • [ 6 ] [Lee, Seunghyun]Department of Electrical Engineering and Creative IT Engineering, POSTECH, Pohang; 37673, Korea, Republic of
  • [ 7 ] [Kim, Won Jong]Department of Chemistry, Postech-Catholic Biomedical Engineering Institute, POSTECH, Pohang; 37673, Korea, Republic of
  • [ 8 ] [Kim, Chulhong]Department of Electrical Engineering and Creative IT Engineering, POSTECH, Pohang; 37673, Korea, Republic of
  • [ 9 ] [Yoon, Juyoung]Department of Chemistry and Nanoscience, Ewha Womans University, Seoul; 03760, Korea, Republic of

Reprint 's Address:

  • [kim, won jong]department of chemistry, postech-catholic biomedical engineering institute, postech, pohang; 37673, korea, republic of

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Source :

Angewandte Chemie - International Edition

ISSN: 1433-7851

Year: 2020

Issue: 22

Volume: 59

Page: 8630-8634

1 5 . 3 3 6

JCR@2020

1 6 . 1 0 0

JCR@2023

ESI HC Threshold:160

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count:

SCOPUS Cited Count: 98

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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