Biomimetic　scaffolds　have　been　a　growing　demand　in　bone　tissue　engineering.　Owing　to　the　performance　shortcomings　of　single　natural　or　synthetic　polymer,　nano　hydroxyapatite　reinforced　hybrid　scaffolds　loading　with　icariin　(icariin-loaded　nHAP/CMCS/PLGA)　were　biomimetically　fabricated　by　emulsion　template　method　combining　organic/inorganic　hybrid　technology.　The　scaffold　successfully　combined　insoluble　polymers　between　water-soluble　carboxymethyl　chitosan　(CMCS)　and　oil-soluble　poly(lactide-co-glycolide)　(PLGA).　In　vitro　physicochemical　properties　and　cytocompatibility　showed　that　the　scaffolds　with　similar　topological　structure　to　the　nature　bone,　and　the　incorporation　of　nHAP　and　icariin　not　only　improved　the　mechanical　properties　and　in　vitro　bioactivity,　but　also　accelerated　the　repair　of　the　damaged　bone　tissue.　In　vivo　osteogenesis　showed　good　biocompatibility　with　the　scaffolds,　especially　the　3.0　wt%　nHAP/CMCS/PLGA　scaffold　(S3)　and　icariin　loaded　3.0　wt%　nHAP/CMCS/PLGA　(I-S3)　scaffold,　they　effectively　promoted　the　adhesion,　proliferation　and　differentiation　of　the　osteoblast.　In　conclusion,　the　icariin　loaded　nHAP/CMCS/PLGA　scaffolds　fabricated　by　emulsion　template　and　organic/inorganic　hybrid　technology　holds　great　potential　and　provides　a　unique　strategy　for　bone　repair　and　regeneration.　©　2020　Elsevier　B.V.