Bacterial　induced　infection　is　a　major　complication　associated　with　the　use　of　medical　implants.　Degradable　antibacterial　ciprofloxacin-polyurethanes　(CFPU)　have　been　synthesized　in　attempts　to　address　this　problem.　It　is　supposed　that　the　material　may　be　sensitively　hydrolyzed　by　inflammatory　enzyme,　cholesterol　esterase　(CE),　and　the　drug　could　be　released　according　to　the　state　of　infection.　The　enzyme　biodegradation　experiments　showed　an　extra　release　of　ciprofloxacin　when　CFPU　was　incubated　by　enzyme　solutions　than　by　phosphate-buffer　saline　(PBS).　Results　showed　that　the　drug　release　was　enhanced　as　the　concentration　of　the　enzyme　increased.　The　antimicrobial　activities　of　degradation　solutions　were　tested　by　broth　dilution　assay.　The　enzyme　degradation　solutions　exhibited　an　ability　to　kill　bacteria.　The　cell　cytotoxicity　assay　indicated　that　the　degradation　products　were　hypotoxicity　to　human　beings　according　to　the　cytotoxicity　grade　of　United　States　Pharmacopoeia　(USP).