A　system　enabling　coupling　of　pressurized　capillary　electrochromatography　(pCEC)　with　off-column　amperometric　detection　(AD)　is　reported　in　which　conduction　of　the　current　in　pCEC　was　achieved　through　a　cellulose　acetate-coated　porous　polymer　joint,　and　the　effect　of　the　high-voltage　field　applied　to　pCEC　for　AD　was　also　eliminated.　Effects　of　supplementary　pressure　on　the　porous　polymer　joint　and　the　effects　on　AD　of　capillary　columns　of　different　i.d.　were　investigated.　The　performance　of　the　pCEC-AD　system　with　the　porous　polymer　joint　was　evaluated　with　phenol　and　hydroquinone　using　sulfonated　stearyl　methacrylate　monolithic　columns.　The　separation　efficiency　of　the　column　in　pCEC-AD,　using　the　proposed　off-column　detection　with　the　cellulose　acetate　membrane　joint,　was　comparable　with　that　of　pCEC-UV　using　on-column　detection.　Compared　with　end-column　detection　using　a　50　mu　m　i.d.　capillary　column　without　a　joint,　a　higher　signal-to-noise　ratio　was　achieved,　even　using　a　100　mu　m　i.d.　capillary　column　with　a　joint.　Successful　separation　and　detection　of　dopamine　and　epinephrine　were　also　achieved　by　use　of　this　system.