A　facile　and　effective　organic　synthesis　route　was　provided　for　preparation　of　the　carbohydrate　coated　polymer　small　particles.　First,　amino-activated　particles　were　prepared　from　PAN　(polyacrylonitrile)　by　the　heterogeneous　cross-linking　method,　then　the　amino　groups　on　the　particle　were　converted　into　hydrazide　groups　by　N-alkylation　and　hydrazine　activation,　meanwhile　the　length　of　linker　was　prolonged　to　the　designed　value.　FTIR　(Fourier　Transform　Infrared　Spectroscopy)　was　used　to　study　the　reactions　in　the　synthesis　steps　and　to　optimize　part　of　the　synthesis　conditions.　Two　carbohydrates　(maltose　and　heparin)　were　then　directly　coupled　to　the　hydrazide-activated　particles　in　a　relative　high　yield,　the　obtained　particles　were　used　to　interact　with　BSA　(bovine　serum　albumin)　and　typical　heparin-binding　proteins.　All　of　these　particles　had　some　nonspecific　interactions　with　proteins　and　heparin　coated　particles　showed　additional　strong　binding　ability　with　the　heparin-binding　proteins.　Data　also　showed　that　a　longer　linker　length　not　only　weakened　nonspecific　interaction　but　also　increased　the　specific　binding　ability.　As　the　carbohydrate　coated　particles　are　independent,　flexible　and　easily　detectable,　they　should　be　good　acceptors　for　the　diverse　bioactive　studies　of　carbohydrates.