In　this　paper,　we　consider　a　periodic　predator-prey　system　with　mutual　interference　and　impulses.　By　constructing　a　suitable　Lyapunov　function　and　using　the　comparison　theorem　of　impulsive　differential　equation,　sufficient　conditions　which　ensure　the　permanence　and　global　attractivity　of　the　system　are　obtained.　We　also　present　some　examples　to　verify　our　main　results.　(C)　2011　Elsevier　B.V.　All　rights　reserved.