A　Lotka-Volterra　predator-prey　model　incorporating　a　constant　number　of　prey　using　refuges　and　mutual　interference　for　predator　species　is　presented.　By　applying　the　divergency　criterion　and　theories　on　exceptional　directions　and　normal　sectors,　we　show　that　the　interior　equilibrium　is　always　globally　asymptotically　stable　and　two　boundary　equilibria　are　both　saddle　points.　Our　results　indicate　that　prey　refuge　has　no　influence　on　the　coexistence　of　predator　and　prey　species　of　the　considered　model　under　the　effects　of　mutual　interference　for　predator　species,　which　differently　from　the　conclusion　without　predator　mutual　interference,　thus　improving　some　known　ones.　Numerical　simulations　are　performed　to　illustrate　the　validity　of　our　results.　(C)　2013　Elsevier　B.　V.　All　rights　reserved.