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Abstract:
A general and convenient copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described. Variation of the solvent, additives and time allowed optimization of the reaction. A wide range of alkyl halides were explored to give a set of alkyl trifluoromethyl thioethers in moderate to excellent yields. A variety of functional groups, including ethers, thioether, esters, nitriles, amides, and ketal groups, were well tolerated in the electrophilic partner.
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ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN: 1477-0520
Year: 2014
Issue: 29
Volume: 12
Page: 5500-5508
3 . 5 6 2
JCR@2014
2 . 9 0 0
JCR@2023
ESI Discipline: CHEMISTRY;
ESI HC Threshold:268
JCR Journal Grade:1
CAS Journal Grade:3
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