Traditional　tissue　engineering　procedures　are　expensive　and　time　consuming.　Facilitated　endogenous　tissue　engineering　(FETE)　provides　a　solution　that　can　avoid　the　ex　vivo　culture　of　autologous　cells　and　initiate　in　situ　reparative　endogenous　repair　processes　in　vivo.　This　method　involves　fabricating　a　porous　scaffold　that　mimics　the　environment　present　during　the　bone　formation　process,　consisting　of　components　that　provide　biomimetic　interfacial　interactions　to　cells.　After　the　scaffold　is　implanted,　progenitor　cells　provided　by　autologous　bone　marrow　and　surrounding　tissues　then　differentiate　to　bone　cells　under　the　direction　of　the　in　situ　scaffold.　This　paper　reports　a　biomimetic　method　to　prepare　a　hierarchically　structured　hybrid　scaffold.　Bone-like　nano　hydroxyapatite　(HA)　was　crystallized　from　a　collagen　and　chitosan　(CC)　matrix　to　form　a　porous　scaffold.　The　in　vivo　study　demonstrates　that　this　nanohybrid　scaffold　supports　excellent　bone　repair.　This　means　that　the　FETE　approach,　in　which　the　cell　culture　portion　of　traditional　tissue　engineering　takes　place　in　vivo,　can　promote　the　intrinsic　regenerative　potential　of　endogenous　tissues.　(C)　2015　Elsevier　B.V.　All　rights　reserved.