Palladium　(Pd)-based　catalysts　are　appealing　electro-catalysts　for　alcohol　oxidation　reaction　in　fuel　cell,　but　still　not　efficient　as　the　complicated　oxidation　process　and　sluggish　kinetic.　Here　we　rationally　design　and　synthesize　a　PdRuBi/NG　tri-metallic　catalyst　with　space　synergetic　effect　for　enhanced　ethylene　glycol　electro-oxidation,　in　which　both　Ru　and　Bi　in　the　catalyst　are　synergistic　effective　in　promoting　catalytic　activity　of　Pd　catalytic　interlayer　by　electronic　effect　and　surface　modification　mechanism　respectively.　It　shows　4.2　times　higher　peak　current　density　towards　ethylene　glycol　electro-oxidation　than　commercial　Pd/C　catalyst,　and　the　catalytic　durability　is　also　greatly　improved.　(C)　2016　Elsevier　Ltd.　All　rights　reserved.