Based　on　the　crystal　structure　of　spinel,　we　applied　the　thermodynamic　ternary　sublattices　model　to　investigate　the　site　occupancy　ordering　behaviors　of　Zn2+,　Ni2+,　Mn2+　and　Fe3+　on　the　8a　and　16d　sublattices　in　the　ZnxMn1-x,Fe2O4　and　NixMn1-xFe2O4　by　combining　thermodynamic　calculations　with　first-principles　calculations.　Our　results　suggest　that　in　the　manganese　ferrites,　Mn2+　occupies　the　8a　sublattice　completely,　and　Fe3+　occupies　the　16d　sublattice　at　room　temperature,　which　belongs　to　a　normal　spinel.　The　site　configuration　is　(Fe0.093+Mn0.912+)　[Fe1.913+Mn0.092+]O-4,　when　the　ferrite　is　subjected　to　the　heat　treatment　of　1　273　K.　When　the　temperature　increases　to　1　473　K,　the　site　configuration　is　(Fe0.113+Mn0.892+)[Fe1.893+Mn0.112+]O-4,　which　agrees　well　with　the　available　reliable　experimental　results.　In　the　zinc　ferrites,　Zn2+　occupies　the　8a　sublattice　completely,　and　Fe＇　completely　occupies　the　16d　sublattice　at　room　temperature.　It　also　belongs　to　normal　spinel,　and　the　cations　trend　to　exchange　the　site　occupancy　each　other　at　higher　temperature.　In　the　Ni　ferrites,　all　Ni2+　occupies　the　16d　sublattice,　and　the　Fe3+　cations　occupy　both　the　8a　and　the　16d　sublattices,　which　agrees　with　the　experimental　results.　It　belongs　to　an　inverse　spinel.　Then,　the　relationship　between　the　occupancy　behaviors　and　the　composition,　as　well　as　the　heat　treatment　temperature　in　the　ZnxMn1-xFe2O4　and　NixMn1-xFe2O4　were　established　based　on　theoretically　predictions.