C-Phycocyanin　(CPC)　as　a　tumour-associated　macrophage　(TAM)-targeted　photosensitiser　has　been　first　proved,　and　used　as　a　vehicle　of　zinc　phthalocyanine　(ZnPc)　to　fabricate　a　ZnPc-CPC　conjugate,　which　exhibits　an　efficient　in　vitro　photodynamic　activity,　and　selectively　accumulates　in　tumour　sites　probably　due　to　the　affinity　to　TAM.