An　innovative　high-performance　precast　beam-to-column　joint　for　multi-storey　framed　structures　is　introduced.　The　proposed　solution　consists　of　coupling　between　Composite　Steel　Truss　Concrete　(CSTC)　beams　with　a　concrete　base　and　High-Strength　Concrete　(HSC)　columns.　This　paper　focuses　mainly　on　the　static　performance　of　prefabricated　HSC　columns,　including　experimental　and　numerical　investigations.　The　finite　element　model　of　the　structural　system　is　calibrated　on　experimental　static　testing　evidence.　On　the　basis　of　the　data　collected,　the　finite　element　model　is　used　to　evaluate　the　strength　domain　of　members　and　optimize　the　related　coupling　system　between　columns.　Aiming　to　limit　time-consuming　analyses　and　provide　practical　rules　for　design,　an　analytical　simplified　procedure　is　introduced　to　compute　the　assembly＇s　strength　domain.　An　analytical　approach　is　adopted　to　estimate　the　reference　design　strength　for　the　considered　composite　columns,　accounting　for　the　partial　safety　factor　imposed　by　codes　and　allowing　for　estimation　of　the　limit　on　the　number　of　storeys　for　frames　adopting　the　proposed　precast　technology.