The　insufficient　catalytic　stability　of　Cu-based　catalysts　is　still　its　bottleneck　in　industrial　application,　and　it　is　widely　studied　how　to　synthesize　highly　stable　Cu-based　catalysts.　Herein,　we　have　developed　a　MOF-derived　preparation　of　robust　Cu/SiO2　catalyst　for　the　efficient　hydrogenation　of　dimethyl　oxalate　(DMO)　to　ethylene　glycol　(EG).　The　sol　gel　method　was　used　to　in　situ　load　the　HKUST-1　into　SiO2　support　with　only　a　copper　loading　of　7.83%.　The　advantages　of　MOF-derived　Cu/SiO2　catalyst　are　that　copper　species　could　escape　from　severe　coating　by　silica　matrix　and　expose　more　active　sites　with　small　particles　sizes　(4.2　nm).　Furthermore,　it　is　inclined　to　generate　more　stable　Cu2O　reduced　from　Cu-O-Si　units　by　using　MOF　as　precursor.　As　a　result,　more　than　95.0%　selectivity　of　EG　with　a　long　lifetime　of　220　h　was　achieved　over　the　Cu/SiO2-MOF　catalyst.　On　the　contrary,　when　using　the　copper　nitrate　as　the　copper　precursor,　the　prepared　Cu/SiO2-CN　catalyst　with　similar　copper　loading　exhibited　much　lower　catalytic　activity　because　that　copper　species　were　encapsulated　into　SiO2　network　and　difficult　to　be　available　for　reactants.　Therefore,　using　MOF　as　copper　precursor　solves　the　problem　of　high-dispersed　copper　species　but　inactive　by　coating　with　SiO2　matrix.