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author:

Li, Xingshu (Li, Xingshu.) [1] (Scholars:李兴淑) | Lee, Dayoung (Lee, Dayoung.) [2] | Huang, Jian-Dong (Huang, Jian-Dong.) [3] (Scholars:黄剑东) | Yoon, Juyoung (Yoon, Juyoung.) [4]

Indexed by:

EI Scopus SCIE

Abstract:

Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via typeI photoreactions (i.e., not by O-1(2) generation). Herein we demonstrate that a new, nanostructured phthalocyanine assembly, NanoPcA, has the ability to promote highly efficient ROS generation via the typeI mechanism. The results of antibacterial studies demonstrate that NanoPcA has potential PDT applications.

Keyword:

nanodots photodynamic therapy phthalocyanine reactive oxygen species typeI photoreactions

Community:

  • [ 1 ] [Li, Xingshu]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 2 ] [Huang, Jian-Dong]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China
  • [ 3 ] [Li, Xingshu]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
  • [ 4 ] [Lee, Dayoung]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
  • [ 5 ] [Yoon, Juyoung]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

Reprint 's Address:

  • 黄剑东

    [Huang, Jian-Dong]Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350108, Fujian, Peoples R China;;[Yoon, Juyoung]Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

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Source :

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN: 1433-7851

Year: 2018

Issue: 31

Volume: 57

Page: 9885-9890

1 2 . 2 5 7

JCR@2018

1 6 . 1 0 0

JCR@2023

ESI Discipline: CHEMISTRY;

ESI HC Threshold:209

JCR Journal Grade:1

CAS Journal Grade:2

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 282

ESI Highly Cited Papers on the List: 28 Unfold All

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WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 4

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