Antimicrobial　photodynamic　therapy　(aPDT)　is　a　new　therapeutical　modality　highly　advocated　recently　to　meet　the　challenge　of　drug　resistant　bacteria.　In　this　study,　we　developed　a　composite　material　to　combine　silver　nanoparticle,　a　commonly　used　disinfectant,　with　a　potent　photosensitizer　for　aPDT.　Interestingly,　we　found　the　photosensitizer　activated　the　silver　nanoparticles　into　silver　ions　under　light　illumination.　At　the　same　time,　silver　nanoparticles　enhanced　the　generation　of　ROS　by　the　photosensitizer.　Together,　the　two　components　activates　each　other,　leading　to　remarkable　antimicrobial　efficacy　against　not　only　gram-positive　and　-negative　bacteria,　but　also　drug　resistant　bacteria　(Methicillin　Resistant　S.　aureus,　MRSA).　Such　antimicrobial　effect　was　further　demonstrated　on　a　bacterial　infection　model　on　mice.　We　showed　that　the　chemical　treatment,　the　high　temperature　or　the　pressure　during　the　preparation　did　not　affect　the　cellulosic　structures　of　the　fabric　based　on　the　characterization　of　optical,　mechanical　and　thermal　properties　of　the　composite　material.　aPDT　is　typically　a　localized　therapy,　depending　on　the　contact　of　bacteria　to　the　photosensitizers,　while　the　silver　nanoparticles　released　the　silver　ions　into　the　solution　and　can　kill　the　bacteria　thereof.　Thus,　our　current　study　demonstrates　the　complementarity　of　aPDT　and　silver　nanoparticles　and　mutual　promotion　of　antibacterial　effects　to　even　drug-resistant　bacteria.